关键词: 中心静脉置管, 动物模型, 经皮穿刺法

Abstract: Abstract: Objective The central venous catheterization model of New Zealand rabbits was established by percutaneous puncture, which laid the foundation for the experimental study of central venous catheterization. Method Ten New Zealand rabbits exposed to their neck skin, percutaneous external jugular vein into the PICC catheter 7-8 cm and fixed, surgery alone cage feeding.Blood samples were taken at 12 h before operation and 24 h, 48 h and 72 h postoperatively. Immunohistochemistry was performed to detect hs-CRP. Recording the model of vital signs, weight and catheter retention time. Result There were no significant differences in vital signs and body weight between the two groups before and after operation. The survival rate of the model was 100% and the success rate was 100%. There was no significant difference in hs-CRP at each time point (F=2.84, P>0.05). Conclusion The modeling method is economical, simple and easy to use, and has a strong practicality, can be a good simulation of clinical, central venous catheterization to achieve the basic research.

Key words: central venous catheter, animal model, percutaneous puncture