关键词: <, p>, 沙漠干热环境, 姜黄素, 大鼠, 脑组织, 氧化应激<, /p>

Abstract: Abstract: Objective To study the neuroprotective effect of Curcumin on the oxidative stress indexes of heatstroke rats in dry-heat environment of desert． Method The 200 male SPF SD rats，were randomly divided into control group，low-dose Curcumin pretreated group，middle-dose Curcumin pretreated group， high-dose Curcumin pretreated group and solvent group，each group had 40 rats． All the rats were put into the dry heat environment ( temperature of ( 41 ± 1) ℃，humidity 10%) in The Simulated Climate Cabin for Special Environment of Northwest of China． Each group were randomly selected 10 rats to measure oxidative stress indexes-brain malondialdehyda ( MDA) and glutathione( GSH) levels at the time of 0 min，50 min，100 min，and 150 min． Ｒesult There were no significant difference of MDA and GSH levels among the groups at 0 min( P ＞ 0. 05) ． The MDA levels of rat’s brain tissue increased and GSH levels reduced with prolonged in dry heat environment． The MDA and GSH levels of brain tissue of high dose Curcumin pretreatment group compared with the control group and the solvent group， were significantly different ( P ＜ 0. 05) ． Conclusion Curcumin can reduce the MDA levels of brain tissue and increase the GSH level of heatstroke rats in dry heat environment of desert． Curcumin has a protective effect on the heatstroke rats in the dry heat environment of desert．

Key words: <p>desert dry heat environment, Curcumin, rats, brain, oxidative stress</p>