关键词: <, p>, 干热环境, 大鼠, 肠黏膜, 中暑, 病理学<, /p>

Abstract: Abstract: Objective To investigate the changes of blood routines and intestinal mucosal pathologies of different degree heat stroke rats in dry-heat environment of desert． Method Forty eight male SD rats，SFP grade，were randomly divided into normal control group，light heat stroke group，moderate heat stroke group and severe heat stroke groups． Placed in simulated dry-heat environment of desert in The Simulated Climate Cabin for Special Environment of Northwest of China，temperature of ( 41 ± 0. 5) ℃，humidity of ( 10 ± 2) %ＲH，fasting and water deprivation，for ( 50 ± 5) min，( 100 ± 5) min，( 150 ± 5) min respectively to cause light，moderate，severe heat stroke rat models． Then the rats were deep anesthetized and sacrificed immediately with 3% sodium pentobarbital intraperitoneally，samples of venous blood and ileum and colon tissue were collected to examine blood routines and count pathological histology score． Ｒesult Ｒats with accumulated degree of heat stroke，white blood cell count increased gradually，white blood cell count of SHS group compared with the other groups increased significantly ( P ＜ 0. 05) ; red blood cell count and hematocrit of MHS group compared with the NC group and LHS group increased significantly，SHS group increased significantly，too ( P ＜ 0. 05) ; platelet count of MHS group compared with the NC group and SHS group increased significantly ( P ＜ 0. 05) ． The pathology injury score of ileum and colon were significantly increased with increasing heat degree in MHS group and SHS group ( P ＜ 0. 05) ． The ileum pathology injury score of MHS and SHS groups were higher than that of colon ( P ＜ 0. 05) ． Conclusion White blood cell count，red blood cell count，hematocrit of heat stroke rats，in dry-heat environment of desert，were increased，platelet count showed a trend of firstly increased and then decreased，intestinal mucosa pathological changes with increasing heat degree aggravated． Ileum pathology injury compared with colon is more serious． Our results showed that protection of small intestinal mucosa of heatstroke rats is one of the effective way to prevent heat stroke in dry-heat environment，and platelet count decreased may be one of the key parameters to reflect the severe heat stroke．

Key words: <p>dry-heat environment, rat, intestinal mucosa, heat stroke, pathology</p>