关键词: <, p>, 慢性疲劳综合征, 旷场实验, 自发活动, 焦虑<, /p>

Abstract: Abstract: Objective To study the differences of space exploration ability between chronic fatigue syndrome mice and normal mice． Method First of all，the Chronic Fatigue Syndrome ( CFS) mouse model is copied by using compound stimulus method，and then to explore the activity in the open field devices between chronic fatigue syndrome mice and normal mice． Ｒesult The total distance moved and average movement speed in the open field devices was decreased in chronic fatigue syndrome group compared with the normal group; The distance in the out ring was significant decreased in chronic fatigue syndrome group compared with the normal group ( P ＜ 0. 05) ; However the duration of movement and distance in the area was significant higher than control group( P ＜ 0. 05) ． Conclusion The ability of spontaneous and exploratory behavior was reduced in CFS mice，which the levels of avoid tropism and anxiety was increased．

Key words: <p>Chronic Fatigue Syndrome( CFS) , the open field test, locomotion, anxiety</p>