关键词: 分泌性中耳炎, 变态反应, 细胞因子

Abstract: Abstract: Objective To investigate the mechanisms of treating OME with Ambroxol Hydrochloride tablets and Bromhexine Hydrochloride injection． Method The animal model of OME was made and was treated with Ambroxol Hydrochloride tablets ( AH) and Bromhexine Hydrochloride injection ( BH) ． At the date of 7 and 14，the middle ear rinses and serum were collected． The levels of IFN-γ，IL-4，LTC-4，PGD2 and PAF were detected．Ｒesult Compared with normal saline group，the levels of IFN-γ，IL-4，LTC-4，PGD2 and PAF of the experimental group that treated with AH and BH were significantly decreased ( P ＜ 0. 05) at the date of 7，but the differences of other parameters between the control group and the experimental group that treated with AH and BH were not significant． At the date of 14，compared with the control group，the differences of the levels of IFN-γ，IL-4，LTC-4，PGD2 and PAF of the experimental group that treated with AH and BH were not significant ( P ＞0. 05) ． Conclusion The mechanism of action of Ambroxol Hydrochloride tablets and Bromhexine Hydrochloride injection is related to inhibiting type I allergy．

Key words: OME, allergic reaction, cytokine