关键词: SD大鼠, 经产, 乳腺增生病, 肝郁气滞

Abstract: Objective To establish a muhiparous rat cycloma8topathy model．Methods Twenty muhiparous female rats were divided into normal and model groups，and the latter were injected through muscular with oestradiol benzoate for ten times at a dose of 1．0 mg·kg～once every two days．From the last injection of oestradiol benzoate， luteosterone was given to rats for 5 days．In the whole procedure。rats were enclosed into fastening cages at night every two days for 1 5 times．After last injeetion of luteosterone，rats were sacrificed and galactophore were collected．Resul侮The number of gland alveolus increased more obviously than that of the normal groups，the volume of gland alveolus inflated．the acinar luminas expanded and the wall of gland alveolus was thinner and filled fully with basophilia secretion．All of those changes didn’t recover to normal levels in 3 weeks．Conclusion Muhiparous rat cycloma8topathy model can be established by hormones induction combined with fastening method． According to our study。this method is reliable。effective and simple．

Key words: SD rat, multiparous, cyclomaBtopathy, stagnation of Qi due to depression