关键词: 性激素, 前列腺增生模型, 前列腺指数

Abstract: Objective This study aimed to observe the histomorphological change of prostate induced by different sex hormone in castrated mice．Methods A total of 40 balb／c mice were randomly divided into 5 groups：normal control(Group N)；castration group(Group C)；3-estradiol treated group(Group E)；testosterone treated group (Group T)；B-estradiol and testosterone treated group(Group R)．Four weeks later，serum androgen and estrogen levels were assayed by ELISA．The prostate indexes were calculated and histological change was examined by HE staining．Results In comparison with normal group，the prostate indexes were increased in groups treated with different sex hormone．which was most obvious in Group R(尸<0．05)．Epithelial cell atrophy was noted in Group C by HE staining．Remarkable prostatic epithelial hyperplasia was observed in Group T but stromal hyperplasia is not obvious．The marked stromal hyperplasia was seen in Group E and prostatic epithelium was significantly reduced relative to normal prostate．Both Prostatic epithelial and stromal hyperplasia were observed in Group R．In addition，inflammatory infiltration around the vessels and acini was viewed in Group R．C：onclusion The components and degrees of prostatic hyperplasia were different with sex hormone status．The androgen mainly caused the prostatic epithelial hyperplasia hut not the．stromal hyperplasia and the obvious stromal muscle’s hyperplasia around the anci was seen after the estrogen treatment．The epithelial and strumsl hyperplasia associated with inflammatory infiltration were induced by the treatment with androgen and estrogen．

Key words: sex hormone, benign prostatic hyperplasia, prostatic index