关键词: 鹿茸, 孕鼠, 胎鼠

Abstract: Objective To explore the effects of pilose antler on pregnant and fetal mice．Methods Kunming mice were divided randomly into two groups．In group A，there were 24 males and 48 females，and they were caged together at the rate of 1：2(male：female)．From the fifth to the fourteenth day after pregnant。females were administrated by oral gavage with pilose antler at three doses，3 mg·kg一1d一1．6 mg·kg一1d一1 and 12 mg·kg一1d一1．In group B，48 male mice administrated with pilose antler for 60d were caged together with females at the rate of 1 ：2(male：female)．The conception rate，body weight of the pregnant mice，stillbirth rate，rate of fetal absorption， placental weight，uterine and fetal mice weights，appearance of the fetal mice，as well as viscera and skeletons， were examined．Results Compared to the control group in the 18th day，body weight，stillbirth rate，birth rate of absorption，appearance of the fetal mice，visceral and skeletal malformations in the high dose group of group A were statistically high(P<0．05)；with the increase of the dose，there is no statistical differences in the aspect of placental，uterine and fetal mice weights．In group B，middle dose group showed a significant increase in pregnancy rate(P<0．05)；With increase of dose，stillbirth rate，birth rate of absorption，weight of placenta， uterine and fetal mice had no significant differences(P>0．05)；there is no impact on malformation of the fbtal mice．Conclusion Administration of high·dose pilose antler during pregnancy can decrease the weight of pregnant mice，but increase the stillbirth·rate，absorption rate in births，and fetal malformation of appearance，viscera and skeletons．Middle-dose administration to males can raise conception and does not induce deformities in fetal mice． Key words：

Key words: Pilose antler, Pregnant mice, Fetal mice