关键词: 体外循环, 模型

Abstract: Objective To establish the postoperatively survived rabbit model of non-transthoracic cardiopulmonary bypass(CPB) without blood pre-filling.Methods Seven rabbits weighting 2.5 to 3.0 kg were used in this study.CPB was established via right carotid artery perfusion and right internal jugular vein cannulation.During CPB,the rabbits were maintained at 37℃ for 60 minutes,then weaned from the CPB.The arterial pressure and blood gas parameters were monitored during CPB.Results CPB model was established in six rabbits,and they were successfully weaned from bypass and ventilator.Five of six were survived more than 24 hrs,and another survived only 6 hrs.One rabbit died of acute left heart failure during CPB surgery.Conclusion The rabbit model of cardiopulmonary bypass is simple and feasible,and the success rate is stable.A good perfusionist is very important in this operation.This model eliminates pre-filling blood effect and can be used to the study on the systemic inflammatory response caused by CPB.

Key words: Cardiopulmonary bypass, Model, Rabbit