关键词: 脂肪肝, 小鼠模型, 乙硫氨酸

Abstract: Objective To study the effects of ethionine on lipid metabolism in mice,in order to provide a gist of decision-making for the time of drug administration for preventing fatty liver in mice.Methods Mice were divided to six groups.serum TG and TC or hepatic TG and TC were detected in normal group,and experimental group at the different time(6,12,24,36,48 h)after taking ethionine orally.Result Serum TG increased significantly during 6～48 h,and serum TC was increased significantly during 6～36 h after ethionine administration.Furthermore hepatic TG was increased significantly during 6～36 h,and hepatic TC was reduced significantly during 24～36 h after ethionine administration.Conclusion Ethionine-induced fatty liver in mice was stable during 6～36 h after administration.

Key words: Fatty liver, Mouse model, Ethionine, Lipid metabolism