关键词: 大鼠, 肝移植手术, 麻醉和麻醉剂

Abstract: Objective To compare the anesthetic effect of ketamine hydrochloride,pentobarbital sodium,and trichloro acetaldehyde hydrate in SD rat liver transplantation surgery,and selected the suitable drugs and doses to rats liver transplantation.Methods Sixty SD rats were divided randomly into three groups treated with the three anesthetic drugs respectively.The anesthetic efficiency,respiratory excretion,body temperature,heart rate and respiratory rate were compared,and the low dose of anaesthetic method was found to be the best.Liver cirrhosis was induced in 102 SD rats,which were anaesthetized using the preferable anaesthetic method and used in liver transplantation surgery.Results All of the three anesthetic drugs were effective,but different in terms of the complexity of the operation,the duration of anesthetic effect,and the adverse reaction.Rats waked up quickly and recovered better when low dose of pentobarbital sodium or trichloro acetaldehyde hydrate was given in the liver transplantation surgery.Conclusion In a complex surgery,such as rat liver transplantation,it is necessary to make the animal wake up quickly using the preferable anesthetic drugs and dosages and the low dose of anaesthetic method could get the good results.

Key words: Rat, Liver transplantation surgery, Anaesthesia and anaesthetic drugs