关键词: 肾阳虚, 模型, 评价

Abstract: Objective To establish and evaluate a mice model with kidney-Yang deficiency syndrome caused by overfatigue and sexual overstrain.Methods Mice had been prepared with compulsive swimming and excessive sexual activity induced by Colldege effect for 4 weeks,then general conditions,body temperatures and tongue pictures of the mice were measured.Results Average body temperature of model group was decreased obviously when it was compared with control group while average body temperature of treatment group was much higher than that of the model group.The model group mice had crenated tongues.In addition,the model group mice had the mantel changes as follows: the papillae of the lamina propria was less in density,the phase frequency of basal layer cells remarkably decreased,the thickness of the lamina epithelium and corneum increased obviously.Comparing with the model group,the density of the papillae increased while the thickness of the lamina epithelium decreased in the treatment group.The phase frequency of basal layer cells tended to increase and the thickness of the corneum tended to decrease,but there was no statistical significance.Conclusion A new mice model for studying kidney-Yang deficiency syndrome caused by overfatigue and sexual overstrain based on classical theory of Traditional Chinese Medicine have been developed.The model is highly in accordance with the conception of kidney-Yang deficiency syndrome in Traditional Chinese Medicine theory.

Key words: Kidney-Yang deficiency syndrome, Model, Evaluation