关键词: SPF级, KM小鼠, 血液生理生化

Abstract: Objective To establish normal range and mean values of blood biochemical parameters in SPF KM mice used in long-term toxicity test.Methods Blood samples were taken from SPF KM mice in different age gender and a number of blood biochemical parameters were measured using an antomatic biochemical and analyzer.Results There are significant difference among mice of different age on WBC、MCH、MCHC、PLT.There are significant difference among day old and sex on RBC、HGB、HCT、Glu、ALT、CHOL、TP、Alb、Glb、A/G、BUN、PO_4、Na、K、Cl、Ca、AG. Concolusion The physiological and biochemical data were significant difference among different age and gender in SPF KM Mice.The normal range and mean values of all data were obtained.This result could be used as normal physiological and biochemical value in SPF KM mice.

Key words: SPF, KM Mice, Physiological and biochemical of blood