关键词: 小型猪, IVGTT, 血糖, 胰岛素, HbAlc

Abstract: Objective To compare the intravenous glucose tolerance test(IVGTT),serum glucose,serum insulin and plasma HbA1c in three different minipig strains.Methods Four month old Guangxi Bama minipigs and Guizhou minipigs,and five month old Wuzhi Shan minipigs were conducted with intravenous glucose tolerance test,and their serum glucose was detected by routine biochemical methods,serum insulin was detected by chemiluminescence,and HbAlc was detected by radioimmunoassay(RIA).All animals were kept under the same conditions during the test.Results In IVGTT test,serum glucose reached peak concentrations after 10 minutes of the glucose injection,and it fall to base level at 60 and 90 minutes in Guizhou minipigs and Bama minipigs respectively.Serum glucose in Wuzhi Shan minipigs fall to the base level at 120 minutes,which was higher than that of Guangxi BaMa minipigs and Guizhou minipigs at the time points during 30 minutes to 90 minutes(P<0.05).Among the three strains the value of HbAlc were higher in Guizhou minipigs(P>0.05),and lower in Wuzhi Shan minipigs (P<0.01).There were no significant differences of blood glucose concentration and insulin sensitivity among the three strains(P>0.05).Conclusion The serum glucose and related parameters were similar among three minipig strains.And the expression were similar too in IVGTT with a little difference in Wuzhi Shan minipigs.

Key words: Minipig, IVGTT, Serum glucose, Insulin, HbAlc