关键词: 裸小鼠, 普通环境, IVC, 生产繁殖

Abstract: Objective To observe reproductive capacity of BALB/C-nu in IVC cages at conventional facility.Methods Three pairs of BALB/C-nu stocks(the ratio of female to male was one to one.) were introduced and the BALB/C-nu stocks were mated in pairs,and the expanding population of blood relationship from offspring was reproduced(the ratio of female to male was three to one,or one to one) in IVC cages at conventional facility.Results The average number born from ten births in BALB/C-nu stocks was 8.6±1.02(nude mice: 1.82±0.63),the average number born from 42 births in the expanding population of blood relationship(the ratio of female to male being three to one) was 6.92±1.47(nude mice: 3.52±1.29),and the average number of nude mice born from 12 births in the expanding population of blood relationship(the ratio of female to male being one to one) was 4.25±1.36.The quality of the nude mice was in keeping with SPF standards.Conclusion The certified nude mice could be reproduced in IVC cages at conventional facility if only the rigorous indoor disinfection and sterile working on purification working stable were carried out.

Key words: Nude mice, Conventional facility, IVC, Reproduction