关键词: 骨缺损, 移植, 病理

Abstract: Objective To observe the effects of different grafting materials(that is,complex material of the osteoblasts from self-periosteum and calcined bone coated with collagen,complex material of osteomorphogenetic protein and fetal bone,and complex material of decalcified bone matrix gelatin and red bone marrow) on repairing of bone defects in rabbits by pathology.Methods The model of bone defects of rabbit's radii on two sides were developed,three kinds of complex material were respectively transplanted to bone defects of rabbit's radii on right side and no complex material was transplanted to bone defects of rabbit's radii on left side as controls,and the effects of different grafting materials on repairing of bone defects were observed by pathology.Results A large number of osteoblasts were seen around calcined bone coated with collagen and a few osteoid tissues were found four weeks after complex material of the osteoblasts from self-periosteum and calcined bone coated with collagen was transplanted,trabeculation of bone was found eight weeks after it was transplanted,and lamellar bone,mature osteocytes,and marrow cavity were found sixteen weeks after it was transplanted.The other two complex materials also possessed osteogenic actions.Conclusion By comparison,the osteogenic action of complex material of the osteoblasts from self-periosteum and calcined bone coated with collagen was better than other two complex materials.

Key words: Bone defects, Implanting