关键词: 屏障环境, IVC, 脏器重量, 脏器系数

Abstract: Objective To measure and analyze the main organ weight and coefficients of SD rats in a barrier system and individually ventilated cages.Methods Total 60 SD rats were used in this study,30 in each group.The rats were raised in a barrier system and IVC for 120 days.The main organ weight and coefficient for heart,liver,spleen,lung,kidney;adrenal,brian testis uterus,ovary were then measured using an electronic scales.Result between female SD rats,spleen weight showed significant difference(P<0.01),all organ coefficients were no significant differences(P<0.05);Between male SD rats,all organ weight were no significant difference(P<0.05),kidney coefficient showed significant differences(P<0.05);between female and male,in a barrier systems and IVC,all organ weight showed very significant differences(P<0.01),between female and male in IVC,no differences were found in the liver and kidney coefficients(P<0.05);between female and male in close system,the organ coefficient of the heart,spleen,lung,adrenal and brain showed significant the difference(P<0.05).Conclusion The organ weight and coefficient of SD rats in a barrier system and IVC were not different significantly.

Key words: Barrier system, Individually ventilated cage(IVC), Organ weight, Coefficient of organ