关键词: 光照制, BALB/c裸小鼠, 血细胞

Abstract: Objective To study the effect on peripheral blood parameters of different lightingregimens in BALA/c nude mice.Method The BALB/c nude mice were divided into three groups:(16 h bright 8 h dark),normal illumination group(12 h bright 12 h dark),and short illumination group(8 h bright 16 h dark).The animals were maintained in three different lightingregiments,to produce second generation to 70 days old,then the peripheral blood parameters were measured,including 15 indexes altogether.Result In the long illumination group and the short illumination group,compared with the normal illumination time group,the hemoglobin determination(HGB) and the red blood cell pressure accumulates(HCT) were both lower.In the long illumination group,compared with the normal illumination group,MTD and the GRA quantity were higher.The short illumination group compared with the normal illumination group,GRA% were lower and LYM% were higher,and PLT were higher.Conclusion The different lightingregiment can create the certain disturbance to the mouse blood corpuscle,normal illumination creates the disturbance is smaller,and suits mouse maintenance.

Key words: Lightingregimen, BALB/c nude mice