关键词: 老年性痴呆, 动物模型

Abstract: Objective To observe and analyse behavioral characteristics of the rats in four kinds of animal models of learning and memory disturbances(model of aged rat,the animal model of learning and memory disturbances caused by damaged basal forebrain,caused by injection of scopolamine,and caused by ligation of bilateral carotids) used commonly in pharmacological study.Methods The learning and memory ability of the rats,spatial cognitive ability of the rats, and excitability and emotion of the rats in new circumstance were observed by water maze and open field tests in the four model groups,control group of young rats,and control group of pseudo-operation.Results The learning and memory ability of the aged rats was significantly decreased and they became more nervous in the new circumstance,with normal spatial cognitive ability and excitability.The learning and memory ability and spatial cognitive ability of the rats of damaged basal forebrain were markedly decreased,but their excitability and emotion in the new circumstance were normal.In the model group of injection of scopolamine,the learning and memory ability and spatial cognitive ability of the rats were decreased and their excitability in the new circumstance was enhanced.In the model group of ligation of bilateral carotids,the learning and memory ability and spatial cognitive ability of the rats were markedly decreased,but their excitability and emotion in the new circumstance were normal.Conclusion These results could come up with background information that would be beneficial to better uses of the four kinds of animal model of learning and memory disturbances in the pharmacological studies.

Key words: Aged dementia, Animal model, Behavioral analysis