关键词: 无毛小鼠, 皮肤, 胸腺, 组织学

Abstract: Objective To study how the mutation gene affects the thymus and skin of the C 57BL/6 hairless mice. Methods The procedure of shedding hair and histological structure on the thymus and skin of the C 57BL/6 hairless mice in 19 days were studied,and compared with C 57BL/6 mice of the same age. Results The C 57BL/6 hairless mice developed a normal coat up to the age of 12 days,but then lost all hair.At the age of 4 weeks the hairless-like mutant mice become essentially naked except for some vibrissae,and grew no new hair.With increased age,the mutant skin form folds and flaps and had rhinoceros-like appearance.The claws were noticeably elongated.Mutant mice had heavily pigmented skin,and had some small papules on the surface of skin.Histologically,There was keratotic cuticular layer in the epidermis.The hair follicle of C 57BL/6 hairless mice in 19 days lost shaft to distend to be lenient cavity, some follicles contained keratin fragments.The Remains of hair papilla became trapped deep in the dermis.Sebaceous glands were well developed.As for the morphology and structure of thymus in 19 days,there was no distinct difference between C 57BL/6 hairless mice and normal mice,but the thymus of hairless mice atrophy early than that of contrast mice. Conclusion The hairless mutant gene effects hair follicles cycle and thymus degeneration of the C 57BL/6 hairless mice.

Key words: Hairless mice, Skin, Thymus, Histology