关键词: 银杏叶制剂, 犬, 抗氧化

Abstract: Objective In order to further understand the pharmacological action of the ginkgo foliage preparation, the dogs made to take orally the great doses of ginkgo foliage preparation and antioxidation indexes of the dog plasma were measured. Methods Six dogs were selected and took orally once ginkgo foliage capsule at a dose of 100 mg/kg body weight. The 5.0mL blood was collected through the hypodermic vein of the forelimbs on selective time. By using conventional kit, antioxidation indexes were measured. Results The activation of SOD in the dog plasma reduced after giving the medicine, and especially significantly reduced between 7 hours and 24 hours. The content of MDA went down in 5 hours after giving the medicine, and then increased between 7 hours and 24 hours. Conolusion It is suggested, if the doses of ginkgo foliage preparation are beyond the normal limit, the capability of antioxidation abates, because ·O 2- produces in the body cumulates.

Key words: Ginkgo foliage preparation, Dog, Antioxidation