关键词: 突变小鼠, 杂交小鼠, 免疫指标

Abstract: Objective To sthdy the immune function of BALB/c hairless mutant mice.Methods The percentages of CD4\++,CD3\++,CD8\++,CD19\++ lymphocytes and IgG level were examined by FCM and ELISA. Results\ In two_week male mice the percentages of CD19\++,CD4\++/CD8\++ lymphocytes were higher than in female mice .The percentage of CD8\++ cells of famale as higer than male. F\-2 Sparse-haired mice the parameters of CD4\++/CD8\++ of male were higer than famale .In two-week uncovered mice the parameters of CD19\++,IgG of male were higher than famale two month F\-2 Sparse_haiged mice the parameters of CD8\++ of famale were higher than male .In F\-2 uncovered mice the parameters of famale were higher than male .The parameters of the hairless mice were lower than those of Sparse-haired mice on two weeks and two months.Conclusion The mutant and also BALB/c hairless mice affected skin and coat structure affected the immune function.

Key words: Hairless mice, Hybridize mice, Immunity celluar