关键词: 博莱霉素, 透明质酸, 层粘连蛋白

Abstract: Consecutive changes of HA(hyalnronic acid),LN(Laminin) in BALF and veno us blood were observed in blemycine induced pulmonary fibrosis in rats and correlated to histopathologica l change.Our results showed:(1)The HA level of the vein and BALF on the 7\+\{th\} day in the model group was increased (\%p\%<0 05)or significantly increased (\%p\%<0 01) than those in the normal control group.(2)The LN levels from vein on the 7\+\{th\} d ay and 28\+\{th\} day in model group were higher significantly than those in the normal control g roup (\%p\%<0 01);there was no significal difference of the BALF and LN levels on the 7\+\{th\} day and 28\+\{th\} day .(3) HA and LN acummulation in vein and BALF preceded the collagen deposition in the lung. Our results signified that increa sed HA and LN level occurred in the early stage, and their falling reflected the presence of fibrosis. HA and LN, particularly HA, are the sensitive index t o reflect the early stage of pulmonary fibrosis(lung injury stage)

Key words: Blemycine, HA, LN, Consecutive changes