疏肝中药复方对慢性束缚应激大鼠下丘脑—垂体—肾上腺轴的调节

实验动物科学

疏肝中药复方对慢性束缚应激大鼠下丘脑—垂体—肾上腺轴的调节

赵歆,陈家旭,杨建新,李伟,刘晓兰,康纯洁,刘燕

北京中医药大学基础医学院中医诊断系,北京中医药大学基础医学院中医诊断系,北京中医药大学基础医学院中医诊断系,北京中医药大学基础医学院中医诊断系,北京中医药大学基础医学院中医诊断系,北京中医药大学基础医学院中医诊断系,北京中医药大学基础医学院中医诊断系北京100029 ,北京100029 ,北京100029 ,北京100029 ,北京100029 ,北京100029 ,北京100029

收稿日期:2003-06-25 修回日期:2003-06-25 出版日期:2003-06-25 发布日期:2003-06-25

Study on the Mechanism of the Regulation of HPA on Chronic Restrained Stress Rat by Compounded Prescription of Smoothing the Liver of Traditional Chinese Medicine

ZHAO Xin, CHEN Jia xu, YANG Jian xin, LI Wei, LIU Xiao lan, KANG Chun jie, LIU Yan

(Beijing University of Chinese Traditional Medicine, Beijing\ 100029

Received:2003-06-25 Revised:2003-06-25 Online:2003-06-25 Published:2003-06-25

摘要/Abstract

摘要： 目的　从神经内分泌学角度探讨慢性束缚应激的发生机制及疏肝中药对其调节作用。方法　建立慢性束缚应激大鼠模型 ,通过行为学实验评估大鼠应激状态下的行为变化 ,并测定大鼠肾上腺、胸腺指数及体内单胺递质含量变化 ,通过对疏肝中药复方柴胡疏肝散的防治作用的观察探讨中药复方的作用机理。结果　柴胡疏肝散可对抗应激引起的体能及情绪改变 ,并对各种单胺递质有不同的调节作用。结论　柴胡疏肝散在一定程度上调节了慢性束缚应激模型动物的行为表现 ,而且使不同组织单胺递质含量呈现动态变化趋势 ,提示其参与慢性束缚应激的内在调节

关键词: 柴胡疏肝散, 单胺类神经递质, 肝(中医), 慢性束缚应激

Abstract: Objective To investigate the effects of chronic restrained stress for the viewpoints of the neuro endocrinol disorder and the regulation of the mediation of Compounded Prescribtion of Smoothing the Liver of the Traditional Chinese Medicine(TCM).Method A stressed model was built by chronic restrained stress for 3h per day. Evaluating the behavior changes, measuring the ratio of the adrenal gland and the thymus grand and the content of monoamine neurotransmitter, and abserving the effect of the Chai Hu Shu Gan San to discuss the mechanism of the Compounded Prescribtion of Smoothing the liver. Result The Chaihushugansan can alleviate the changes of the physical strength and the emotion, and mediate different monoamine neurotransmitter.Conclusion Chai Hu Shu Gan San can improve the dysfunction of chronic restrained stress situation in some degree.

Key words: Chai Hu Shu Gan San, Chronic restrained stress, Liver(TCM), Monoamine neurotransmitter

赵歆,陈家旭,杨建新,李伟,刘晓兰,康纯洁,刘燕. 疏肝中药复方对慢性束缚应激大鼠下丘脑—垂体—肾上腺轴的调节[J]. 实验动物科学.

ZHAO Xin, CHEN Jia xu, YANG Jian xin, LI Wei, LIU Xiao lan, KANG Chun jie, LIU Yan. Study on the Mechanism of the Regulation of HPA on Chronic Restrained Stress Rat by Compounded Prescription of Smoothing the Liver of Traditional Chinese Medicine[J]. laboratory animal science.