多奇胶囊对大鼠实验性骨质疏松症的影响

实验动物科学

多奇胶囊对大鼠实验性骨质疏松症的影响

胡春萍,章熙霞,许立

江苏省中医药研究院,南京市家禽研究所,江苏省中医药研究院南京210028 ,南京210016 ,南京210028

收稿日期:2003-06-25 修回日期:2003-06-25 出版日期:2003-06-25 发布日期:2003-06-25

Effect of Duoqi Capsule on Experimental Osteoporosis of Mice

HU Chun ping 1, ZHANG Xi xia 2, XU Li 1

(1. Institute of TCD of Jiangsu Province, Nanjing\ 210028) (2. Institute of Nanjing Poultry, Nanjing\ 210016

Received:2003-06-25 Revised:2003-06-25 Online:2003-06-25 Published:2003-06-25

摘要/Abstract

摘要： 目的　多奇胶囊系由雌性金陵乌嘴鸭血和钙剂组成 ,在去势造成的骨质疏松症模型大鼠上观察了该药的药效学作用。结果显示 :1号胶囊能显著提高动物子宫系数 (P <0 0 5 )及骨密度值 (P <0 0 5和P <0 0 1) ,2号胶囊能增高模型动物血中雌二醇 (E2 )水平 (P <0 0 5 ) ,且两药均使模型动物血磷含量明显下降 (P <0 0 1) ,骨矿物质含量显著增高 (P <0 0 5或P <0 0 1)。这些结果表明 ,多奇胶囊能补充机体雌激素 ,维护骨质代谢 ,减少骨质丢失 ,具有防治骨质疏松的作用

关键词: 多奇胶囊, 骨质疏松症

Abstract: Objective\ To observe therapeutic effect of the Duoqi capsule.Method\ Duoqi capsule is composed of the blood of Jinling female Wuya and Calcium, the pharmacodynamics effect of Duoqi capsule on model mice after castration was observed. Results\ Number 1 capsule can improve remarkedly uterus weight of animal ( p <0 05) and skeletal density( p <0 05 and p <0 01). Number 2 capsule can improve the level of estradiol in blood ( p <0 05), and the capsule reduced the level of blood phosphorus. The mineral substance of bone was improved remarkedly ( p <0 05 and p <0 01). Conclusion\ Duoqi capsule can supply body with estrogen, maintain metabolism of bone, reduce osteopenia and prevent osteoporosis.

Key words: Duoqi capsule, Osteoporosis

胡春萍,章熙霞,许立. 多奇胶囊对大鼠实验性骨质疏松症的影响[J]. 实验动物科学.

HU Chun ping 1, ZHANG Xi xia 2, XU Li 1. Effect of Duoqi Capsule on Experimental Osteoporosis of Mice[J]. laboratory animal science.