关键词: 大鼠, 虚寒证, 指标相关性

Abstract: Objective\ To improve the method to erect deficiency and cold syndrome model of rats,the correlation among macroscopic and microcosmic markers were observed and analysed.Methods\ Wistar rats,Ⅱ stage,female,were divided to deficiency and cold syndrome group and control group by temperature of body.Deficiency and Cold syndrome model were erected with feeding cooling drugs that were larger in dosage and longer in time than usual.The macroscopic and microcosmic markers were detected,and their correlations were compared.Results\ Comparing to the control group,the correlations among markers in deficiency and cold syndrome group have their charecteristics.their correlation of different organs' weight (include their exponents)obviously increase.There are negative correlation between their swimming time and activity of LDH,the specific value of cAMP/cGMP and positive correlation between swimming time and content of cGMP.Their weight and exponent of thymus have the positive relation with the specific value of cAMP/cGMP and the content of cortisol,and negative relation with the content of E 2,the specific value of E 2/T.Their diameter of periarterial lymphatic sheath of spleen small artery have a positive correlation with the weight and exponent of spleen.There are obvious correlation between their marker of gastric mucosa and of endocrine system,etc.Conclusion\ Correlation among biology markers should be payed more attention to,because they are the significant physiological and pathological charecter too.

Key words: Rats, Deficiency and cold syndrome, Correlation among markers