生骨片治疗激素性股骨头坏死的实验研究

实验动物科学

生骨片治疗激素性股骨头坏死的实验研究

王婷,宋怀燕,张文明

中国医学科学院实验动物研究所,中国医学科学院实验动物研究所,中国医学科学院实验动物研究所北京100021 ,北京100021 ,北京100021

收稿日期:2003-03-25 修回日期:2003-03-25 出版日期:2003-03-25 发布日期:2003-03-25

Experimental Study on “Sheng-Gu-Pian” for Treatment of Glucocorticoid-induced Avascular Necrosis of Femoral Head

WANG Ting,SONG Huai\|yan,ZHANG Wen\|ming

(Institute of Laboratory Animal Science,Chinese Academy of Medical Sciences,Beijing\ 100021

Received:2003-03-25 Revised:2003-03-25 Online:2003-03-25 Published:2003-03-25

摘要/Abstract

摘要： 目的　观察生骨片对激素性股骨头坏死的治疗作用。方法　选用Wistar大鼠 6 0只 ,分为生骨片高、中、低剂量 (5 4 0g ,2 70g ,1 35g生药 kg)组 ,阳性对照组、模型对照组和空白对照组。连续灌胃给药 15 0d ,测量相关血生化、性激素及骨代谢动力学值。结果　生骨片可降低血清ALP、ACP含量 (P <0 0 5 ) ,促进钙、磷沉积 (P <0 0 5 ) ,生骨片高、中剂量组与模型对照组相比较在钙盐沉积光密度、完整骨小梁相对值和骨小梁总面积等方面均出现极显著性差异 (P <0 0 0 1,P <0 0 1)。结论　生骨片能促进生化代谢和钙磷沉积 ,对激素性股骨头坏死有一定的防治作用

关键词: 生骨片, 激素性股骨头坏死, 实验研究

Abstract: Objective\ To observe the effects of “Sheng\|Gu\|Pian” on Glucocorticoid\|induced avascular necrosis of femoral head.Method\ 60 Wistar rats were divided into 6 groups:the low\|,the middle\|,the high\|dosage(1.35,2.70,5.40g crude drug/kg),the positive drug control,the negative control group and the model control group.The drugs were administered(i.g)daily for 150 days,test the values of serum biochemistry,serum steroid and bone metabolic motivation.Results\ Sheng\|gu\|Pian can decrease the contents of ALP and ACP in serum ( P <0.05),accelerated the sediment speed of serum Calcium and Phosphorus ( P <0.05).Compared with model control group,the high\|and middle\|dosage group were high significant differences in aspects of optical density of Calcium salt sediment,relative value of bone trabecula and total area of bone trabecula.( P<0.001;P<0.01 ).Conclusion\ “Sheng\|Gu\|Pian” can improve biochemistry metabolism and accelerate sediment of serum Calcium and Phosphorous.There are some effects in proventive and treatment for the GANFH.

Key words: Sheng\|Gu\|Pian”, GANFH, Experimental study

王婷,宋怀燕,张文明. 生骨片治疗激素性股骨头坏死的实验研究[J]. 实验动物科学.

WANG Ting,SONG Huai\|yan,ZHANG Wen\|ming. Experimental Study on “Sheng-Gu-Pian” for Treatment of Glucocorticoid-induced Avascular Necrosis of Femoral Head[J]. laboratory animal science.

[1]	张雪梅，李兵，陈立杰，焦卓敏，黄山，尚宏. 电凝法制作Balb/c小鼠局灶性脑缺血模型的实验研究[J]. 实验动物科学, 2019, 36(03): 69-.
[2]	邓超，孔立红. 一种快速取大鼠膝关节滑膜的方法[J]. 实验动物科学, 2019, 36(02): 76-.
[3]	李鹏飞, 贾楠, 沈亚欣, 靳宪辉 . 纤维环缝合术后不同时期椎间盘愈合特征的动物实验研究[J]. 实验动物科学, 2017, 34(04): 36-42.
[4]	朱方石,姒健敏. 萎缩性胃炎实验动物模型的研究状况[J]. 实验动物科学, 2004, 21(01): 35-37.
[5]	钟岚,范建高,王国良,吴伟清,史祺. 肥胖、高脂血症性脂肪性肝炎模型的建立[J]. 实验动物科学, 2000, 17(02): 16-20.