门冬氨酸钾镁氯化钠注射液溶血性试验研究

实验动物科学

门冬氨酸钾镁氯化钠注射液溶血性试验研究

宋宏良,张崇烈,刘爱恒

天津市医药科学研究所,天津市实验动物质量监测站,天津市医药科学研究所天津300070 ,天津300381 ,天津300070

收稿日期:2002-06-25 修回日期:2002-06-25 出版日期:2002-06-25 发布日期:2002-06-25

Study on Haemolytic Effect of Injection Potassium Magnesium Aspartate

SONG Hong-liang+1,ZHANG Chong-lie+2,LIU Ai-Heng+1

(1.The Institute of Medical & Pnarmaceutical Science in Tianjin,Tianjin 300070)(2.Tianjin Station to Inspect and Infer the Quality of the Experiment Animal,Tianjin 300381

Received:2002-06-25 Revised:2002-06-25 Online:2002-06-25 Published:2002-06-25

摘要/Abstract

摘要： 根据国家药品监督管理局颁布的新药审批办法的规定 ,对门冬氨酸钾镁氯化钠注射液的溶血性、全身过敏性、血管刺激性进行试验研究。试验结果表明 ,未见门冬氨酸钾镁氯化钠注射液在体外对红细胞有溶血作用 ;对豚鼠经静脉给药 ,未见有过敏性反应 ;从家兔耳缘静脉点滴 ,上下午各一次 ,连续 7d ,光镜下观察 ,未见血管内皮细胞脱落 ,无血栓形成 ,也未见其它异常

关键词: 门冬氨酸钾镁氯化钠注射液, 溶血性试验, 全身过敏性试验, 血管刺激性试验

Abstract: According to the provision in the guide for examining and approving the new drugs,the haemolytic effect, hypersensitive effect and angio-irratation effect of injection potassium magnesium aspartate were studied.The experiments showed that no haemolyticus effect,hypersensitive effect and angio-irratation effect of injection potassium magnesium aspartate were checked out.

Key words: Injection potassium magnesium aspartate, Haemolytic hypersensitivity, Angio-irratation

宋宏良,张崇烈,刘爱恒. 门冬氨酸钾镁氯化钠注射液溶血性试验研究[J]. 实验动物科学.

SONG Hong-liang+1,ZHANG Chong-lie+2,LIU Ai-Heng+1. Study on Haemolytic Effect of Injection Potassium Magnesium Aspartate[J]. laboratory animal science.