脉瑞康对异丙肾上腺素增加动物心肌耗氧和诱发心肌损伤的作用研究

实验动物科学

脉瑞康对异丙肾上腺素增加动物心肌耗氧和诱发心肌损伤的作用研究

张庚伦,萧英,王丽娟

山东省药品检验所药理科!济南250012,山东省药品检验所药理科!济南250012,山东省药品检验所药理科!济南250012

收稿日期:2001-03-25 修回日期:2001-03-25 出版日期:2001-03-25 发布日期:2001-03-25

Study on the Effect of Mairuikang on the Increase of Cardiac Muscle Oxygen Consumption and Myocardial Injury Induced by Isoprenaline

ZHANG Geng\|lun,XIAO Ying,WANG Li\|juan

(ShanDong Institute for Drug Control,JiNan\ 250012

Received:2001-03-25 Revised:2001-03-25 Online:2001-03-25 Published:2001-03-25

摘要/Abstract

摘要： 脉瑞康大剂量对异丙肾上腺素 (Isoprenaline ,Isop)增加小鼠心肌耗氧有明显抑制作用 ,可显著延长小鼠耐缺氧存活时间 (P <0 .0 5 ) ;脉瑞康大剂量可致心肌损伤大鼠血清活性升高的天门冬氨酸氨基转换酶AST、磷酸肌酸激酶CPK显著降低 (P <0 .0 5 ) ,对活性升高的α -羟丁酸脱氢酶 (α-HBDH)、乳酸脱氢酶 (LDH)有一定降低作用 ,但无显著意义 ,组织病理学检查也显示心肌病理损伤减轻

关键词: 脉瑞康, 异丙肾上腺素, 心肌耗氧, 心肌损伤

Abstract: In the present study,the pharmacological effect of Mairuikang in mouse and rat models were observed.The results showed that the drug could significantly prolong the survival time of mice in condition of hypoxia.It indicated that Mairuikong could reduce the oxygen consumption of cardiac muscle increased by Isoprenaline.Mairuikong could also decrease the increase of activity of rats serum AST,α HBDH,CPK and LDH caused by Isoprenaline in different level.Pathological study showed Mairuikong could reduce the myocardial injury.

Key words: Mairuikang, Cardiac muscle consumption of oxygen, Myocardial injury .

张庚伦,萧英,王丽娟. 脉瑞康对异丙肾上腺素增加动物心肌耗氧和诱发心肌损伤的作用研究[J]. 实验动物科学.

ZHANG Geng\|lun,XIAO Ying,WANG Li\|juan. Study on the Effect of Mairuikang on the Increase of Cardiac Muscle Oxygen Consumption and Myocardial Injury Induced by Isoprenaline[J]. laboratory animal science.

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