兔气虚血瘀型心力衰竭模型的建立

实验动物科学

兔气虚血瘀型心力衰竭模型的建立

曹雪滨,李培建,黄河玲,何建成,胡元会

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收稿日期:1999-09-25 修回日期:1999-09-25 出版日期:1999-09-25 发布日期:1999-09-25

Establishment of The Animal Model of Congestive Heart Failure with Qixu Xueyu syndrome in Rabbits

Cao Xuebin, Li Peijian, Huang Heling, et al. 252 Hospital of PLA, Baoding 071000$$$$〔

Received:1999-09-25 Revised:1999-09-25 Online:1999-09-25 Published:1999-09-25

摘要/Abstract

摘要： 本研究旨在通过反复多次大剂量静脉滴注去甲肾上腺素建立兔气虚血瘀型充血性心力衰竭动物模型。２０只兔随机分为模型组与对照组，模型组动物给予去甲肾上腺素（１ｍｇ／ｋｇ），间日一次，连续应用１５次，对照组动物给予生理盐水。结果证实模型组动物在发生心肌形态学改变的基础上有显著的血流动力学异常，符合充血性心力衰竭的特点。同时模型组动物具有符合中医理论气虚血瘀证的表现，存在血瘀证的客观指标。本文较为成功地建立了气虚血瘀型充血性心力衰竭的动物模型

关键词: 充血性心力衰竭, 气虚血瘀证, 动物疾病模型

Abstract: ? The aim of our study was to establish an animal model of congestive heart failure with Qixu Xueyu syndrome in rabbits. 20 rabbits were divided into a model group and a contral group, and norepinephire were given to rabbits at a dosage of 1mg/kg in the model group. The results suggested that marked myocardial injuries were found in animal of the model group. The ASP\, ADP\, LVSP and ±dp/dtmax in model group were decreased, while the LVEDP was increased. The symptoms of Qixu Xueyu syndrome also existed. Thus, the animal model was succesfully established.

Key words: Congestive heart failure\ Qixu Xueyu syndrome\ Animal model\ Disease

曹雪滨,李培建,黄河玲,何建成,胡元会. 兔气虚血瘀型心力衰竭模型的建立[J]. 实验动物科学.

Cao Xuebin, Li Peijian, Huang Heling, et al. 252 Hospital of PLA, Baoding 071000$$$$〔. Establishment of The Animal Model of Congestive Heart Failure with Qixu Xueyu syndrome in Rabbits[J]. laboratory animal science.

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