关键词: 肺癌, 裸鼠, 侵袭, 移植

Abstract: A highly metastatic giant cell carcinoma (PG) and a poorly metastatic adenocarcinoma (PAa) were orthotopically implanted into nude mice, and the take rates were 74% for PG and 56% for PAa. Invasive tumors located in hilar region or peripheral part of lung, or spread diffusely, which were quite similar to three macroscopic types of primary lung carcinomas and different from well-circumscribed masses of ectopically implanted tumors. It is interesting to point out that the metastatic incidence of PAa cells in regional lymph nodes was 56% when implanted orthotopically which was even higher than the metastatic incidence in beige nude mice bearing subcutaneous tumors. Collectly, the results demonstrate that the orthotopic implantation of human lung carcinomas favour the expression of metastatic phenotype suitable for experimental study of metastasis. The comparation of expressions of oncogenes and antioncogenes in orthotopically implanted tumors with those in subcutaneously implanted tumors of the same kind will contribute to searching for molecular basis of tumor invasion and metastasis.

Key words: lung cancer, Nude mice, Invasion, Metastasis