实验动物科学

• 论文 • 上一篇    下一篇

环境温度对硫酸链霉素异常毒性检定的影响

刘晓冀;何梅英;唐珊波;   

  1. 华北制药厂,华北制药厂,华北制药厂 河北石家庄和平路4号 050015,河北石家庄和平路4号 050015,河北石家庄和平路4号 050015
  • 收稿日期:1992-09-25 修回日期:1992-09-25 出版日期:1992-09-25 发布日期:1992-09-25

Effect of Environmental Temperature on Determining Abnormal Toxicity of Streptomycin Sulfale in Mice

Liu Xiaoji He Meiying Tang Shanbo North China Pharmaceutical Corportion, Shijiazhuang, Hehei Province, 050015   

  • Received:1992-09-25 Revised:1992-09-25 Online:1992-09-25 Published:1992-09-25

摘要: 初步研究了环境温度对硫酸链霉素异常毒性检验的影响。结果表明:环境温度的变化使小鼠对硫酸链霉素异常毒性的耐受力明显降低。几类不同的环境温度条件中,育成室室温的超常,对试验结果的影响最为显著,因此,确保育成室室温的正常和恒定是检验结果准确、稳定的必要条件。

关键词: 环境温度, 硫酸链霉毒, LD_50, 小鼠

Abstract: This study was designed to evalute effect of environmental temperature on the determining abnormal toxicity of streptomycin sulfale. The experimental results showed that resistance to the abnormal toxicity of streptomycin sulfale in mice was significantly redueed by variations of environmental temperature and the effect of the super-normal temperature of rearing room was most marked in several conditions of temperature. The results suggest that keeping normality and constancy of temperature in rearing room is essential to the consistency of determined results.

Key words: Environmental temperature, Streptomycin sulfale, Mice, LD_(50)