实验动物科学 ›› 2026, Vol. 43 ›› Issue (1): 112-116.DOI: 10.3969/ j. issn.1006-6179.2026.01.017

• 综述 • 上一篇    

脊柱侧弯动物模型研究进展

  

  1. (1.甘肃中医药大学中医临床学院,兰州 730000)(2.甘肃省中医院创伤中心,兰州 730050)
  • 收稿日期:2024-11-13 出版日期:2026-01-28 发布日期:2026-02-28
  • 通讯作者: 赵 军(1973—),男,主任医师,研究方向为中医骨伤科学。E-mail:lzzj0001@sina.com。
  • 作者简介:王晓帅(1995—),男,在读硕士研究生,研究方向为中医骨伤科学。E-mail:15512931955@163.com。
  • 基金资助:
    联合科研基金重大项目(23JRRA1529);甘肃省中医药管理局高水平重点课题(CZKZ-2025-5)。

Research Progress in Animal Models of Scoliosis

  1. (1.Clinical College of Chinese Medicine, Gansu University of Chinese Medicine, Lanzhou 730000,China) (2.Trauma Center, Gansu Provincial Hospital of Chinese Medicine, Lanzhou 730050,China)
  • Received:2024-11-13 Online:2026-01-28 Published:2026-02-28

摘要: 青少年特发性脊柱侧弯(AIS)是我国青少年常见疾病之一,其发病机制尚未明确,有学者通过实验动物模拟 脊柱侧弯三维畸形来探索脊柱侧弯发病的分子机制。本文对近5年脊柱侧弯动物模型的研究进展进行综述,以动 物种类为分类依据,对以不同方法建立脊柱侧弯动物模型的简要步骤进行概述,分析不同种类及不同方法建立脊 柱侧弯动物模型的优缺点,旨在为建立脊柱侧弯动物模型的实验研究提供参考。

关键词: 脊柱侧弯, 动物模型, 造模方法, 研究进展

Abstract: Adolescent idiopathic scoliosis (AIS) is one of the common diseases of adolescents in China, and its pathogenesis is not yet clear. Some scholars have explored the molecular mechanism of scoliosis by simulating the three-dimensional deformity of scoliosis in experimental animals. This article reviews the literature on the study of scoliosis in the past five years, summarizes the research progress of scoliosis animal models in recent years, summarizes the brief steps of establishing scoliosis animal models by different method based on animal species classification, analyzes the advantages and disadvantages of different kinds and methods of establishing scoliosis animal models, aims to provide reference for experimental research on establishing scoliosis animal models.

Key words: scoliosis, animal model, modeling method, research progress

中图分类号: