关键词: 先天淋巴细胞, 小鼠模型, 基因敲除

Abstract: Innate lymphoid cells (ILC), a newly identified class of innate immune cells in recent years, exhibit a broad spectrum of functions. Based on their phenotypic characteristics, ILCs can be categorized into three main subsets, ILC1s, ILC2s, and ILC3s. The development of specific animal experimental models offers significant advantages for elucidating the precise biological functions of ILCs. However, the complete and specific ablation of these cells is technically challenging due to the lack of ILC-specific promoters. To overcome this limitation, strategies targeting the upstream regulators of ILC development and functional pathways have been employed to generate animal models with ILC-specific defects. This review systematically summarizes the ILC-deficient mouse models established through diverse strategies, which are based on the distinct functional properties of ILCs, and provides an important theoretical basis for the construction of relevant models in various stages of innate lymphoid cell research.

Key words: innate lymphoid cells, mouse model, gene knockout