关键词: 中药, 镇痛药, 毒理学

Abstract: objective To evaluate the safety of external applied Chinese traditional medicine“Ai zheng zhen tong san”. Method To make use of skin irritation test of rabbit, skin allergy test of guinea pig, skin acute toxicity test of rabbit, skin long term toxicity test of rabbit to carry out the evaluation. Results When“Ai zheng zhen tong san” was external applied under equivalent dose and concentration of clinical use, it doesn't induce allergic reaction in guinea pigs, but has a slightly irritation to rabbit skin. While external applied under high doses, it appeared slightly irritating to rabbit skin in cute toxicity test, and induced skin incrassation and connective tissue hyperplasia in corium layer in long term toxicity test, no systemic toxicity were observed. Conclusion “Ai zheng zhen tong san” is considered safety when it be used as suggesting clinic dose and concentration.

Key words: Chinese traditional medicine, Analgesic