关键词: 氯胺酮, 蚊媒感染实验

Abstract: objective To observe whether the ketamine has any effect on the development of plasmodium in anopheles after the plasmodium infected monkey was given intra muscular injection of ketamine and then exposed to mosquitoes sucking to suck blood. Method The plasmodium infected monkey was exposed to mosquitoes to suck blood and after before being given injection of ketamin. Oocysts and sporozoits of plasmodium in mosquitoes were examined on day 9 and day 12 after mosquitoes sucking blood, respectively. Results The positive rates of oocysts and sporozoite infection of control groups were 100%, the same as those of the ketamine treated groups there was no significant difference ( p >0 1) between the control groups and the ketamine treated groups in the density of oocyst and the average size of oocyst and the average density of sporozoite infection.Conclusion After the plasmodium infected monkey was injected with ketamine and then exposed to mosquitoes to suck blood, there was no influence on the development of plasmodium in anopheles and the mosquitoe sucking blood could be improved and the experiment time could be shortened.

Key words: Ketamine, Anopheles dirus, Plasmodium