实验动物科学

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肝郁脾虚证动物模型的研究进展

彭延娟,彭成   

  1. 成都中医药大学,成都中医药大学 成都610075 ,成都610075
  • 收稿日期:2004-03-25 修回日期:2004-03-25 出版日期:2004-03-25 发布日期:2004-03-25

The Experimental Study Development on Animal Model in Depression of The Liver-Qi and Insufficiency of The Spleen-Qi Syndrome

PENG Yan juan, PENG Cheng   

  1. (Chengdu University of Traditional Chinese Medicine, Chengdu610075,China
  • Received:2004-03-25 Revised:2004-03-25 Online:2004-03-25 Published:2004-03-25

摘要: 对近年来肝郁脾虚证动物模型的研究现状进行了评述 ,对存在的问题进行了分析讨论。肝郁脾虚证动物模型主要有CCl4 ,注射法、高脂饲料饲喂与CCl4 注射联合造模法、夹尾激怒加苦寒泻下法、限食限动加结肠注射醋酸法复制肝郁脾虚证或肝郁脾虚证溃疡性结肠炎病证结合模型 ,为肝郁脾虚证的深入研究开辟了新途径。但还存在一些问题 ,应进一步提高和完善 ,如在造模方法上应尽可能注意与中医传统病因学说的相似性 ,在模型症状指标上应结合动物的生理、病理特征建立起符合动物特性的统一的判断标准 ,并建立起本模型的生物学特征 ,在客观指标的确立上应重视多指标互参 ,在复健方药的选择上应力求标准化

关键词: 肝郁脾虚证, 动物模型, 综述

Abstract: The experimental study on animal model in the depression of the Live Qi and ins ufficiency of the Spleen Qi syndrome in recent years was reviewed, and ana lyzed the problems in it. The methods of making model were as follows:CCl\-4 inj ection, combining high fat diet with CCl\-4 injection, combining the irritating rats by clipping the tails with purging by medicines bitter in taste and cold in nature,combining the limiting diet and movement with coloclyster by acetic acid to make model of the TCM syndrome or ulcerative colitis with the the TCM syndro me. These methods opened the new pass to study this syndrome further. But there were still several problems in these model studies, which should be improved. Fo r example: the etiological similarity with the TCM syndrome, establishing the di agnosis standard and biological feature according to the animal physiological and pathological characteristic, comparing the test index each other, standardi zing the treatment fomular and herbs.

Key words: Depression of the Liver Qi and insufficiency of the Spleen Qi syndrome, Anima l model, Review