关键词: 离体肺, 冷藏, 顺应性, 地塞米松

Abstract: Objective To investigate the change of pulmonary compliance after cold preservation in dexamethasone solution in an isolated lung model.Methods 32 rabbit lungs were randomly divided into two groups.The treated group was divided into 3 parts,preserved for 24h,72h and 120h in dexamethasone solution at 4℃.In the control group,pulmonary compliance was measured at room temperature.In the treated group,after rewarm at room temperature,the lungs were placed in saline solution.And then compliance with pulmonary volume 10mL,20mL and 30mL was measured respectively during infusing with air (saline solution) and drawing air(saline solution).Results Compared to the control group there were no significant differences in compliance of cold-preserved lungs for 24h with infusing with and drawing saline solution,cold-preserved lungs for 72h with infusing with and drawing air with pulmonary volume 10mL,20mL and cold-preserved lungs for 120h with infusing with and drawing air with pulmonary volume 10mL,20mL(P>0.05),but were in that of other treated groups(P<0.05).Conclusion Pulmonary compliance after cold preservation in dexamethasone solution increased,and the effect gradually increased with cold preservation prolongation.

Key words: Dexamethasone, Cold preservation, Isolated lung, Pulmonary compliance