实验动物科学

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MS-302生物信息计算分析系统测定清洁级Wistar大鼠生理学指标的应用

周顺长;杜佐华;彭盛德;   

  1. 华中科技大学同济医学院实验动物学部,华中科技大学同济医学院药理学系,华中科技大学同济医学院药理学系 武汉430030,武汉430030,武汉430030
  • 收稿日期:2006-06-25 修回日期:2006-06-25 出版日期:2006-06-25 发布日期:2006-06-25

MS-302 Analytical System is Used to Determine Physiological Norm on Clean Wistar Rats

ZHOU Shun-chang~1,DU Zuo-hua~2,PENG Sheng-de~2   

  1. (1.Experimental Animals Department of Tongji Medical College,Huazhong Science and Technology University,Wuhan 430030,China)(2.Clinical Pharmacology Research Institute of Tongji Medical College,Huazhong Science and Technology University,Wuhan 430030,China
  • Received:2006-06-25 Revised:2006-06-25 Online:2006-06-25 Published:2006-06-25

摘要: 清洁级Wistar大鼠颈总动脉插管,使用MS-302生物信息计算分析系统接驳计算机,皮下注射生理盐水(0.5mL/100g),比较分析注射前、注射后15ms、30ms、45ms、60ms、75ms、90ms之Wistar大鼠的心率、颈总动脉收缩压、平均压、舒张压、呼吸频率、呼吸张力的变化。结果显示:清洁级Wistar大鼠的心率为331~378次/min,颈总动脉平均血压为92.4~115.9mmHg,收缩压为101.7~129.3mmHg,舒张压为82~110.2mmHg;呼吸频率为56~92次/min,呼吸肌张力为3.8~6.0g。特别是Wistar大鼠呼吸肌张力指标的测定为应用提供了新的参考依据。

关键词: MS-302, 血压, 张力, 呼吸频率

Abstract: Objective Illuminate the method of using MS-302 analytical system to determine some physiological norms of the rats.Method 10 clean Wistar rats were used in this study.To determine the frequency of heart beat,the blood pressure of neck artery,the frequency of breath,the extent of breath muscle of the rats using MS-302 physical analytical system.Result The heart rate was 331~378 beat/min.The average blood pressure was 92.4~115.9mmHg,the average blood contract pressure was 101.7~129.3mmHg,the average blood loosen pressure was 92.4~115.9mmHg.The frequency of breath was 56~92 beat/min,the extent of breath muscle was 3.8~6.0g.Conclusion The MS-302 system provides a good reference foundation in determining some physiological norms of animals.

Key words: MS-302, Blood pressure, Frequency, Breathe