关键词: 钩藤散, 犬, 脑血流量

Abstract: Objective Observe the Goutengsan' effects on cerebral blood flow in anaesthesia dogs.Methods Twenty house dogs were randomly divided into 5 groups.Femoral arterial cannula was performed in animals after anaesthesia and then connected to RM-6000 multichannel physiologic recorder.The common carotid artery and vertebral artety were connected to MFV-3200 electromagnetic flowmeter.Goutengsan at high,middle and low dosages were injected into duodenum whereas the positive control group was injected with Nimodipine(2 mg/kg).The changes of cerebral blood flow,systolic blood pressure,diastolic blood pressure,mean arterial blood pressure and heart rate of the dogs before or after giving drug were monitored.Cerebral vascular resistance were calculated.Results In all experimental groups including positive control group the brain blood flow was obviously higher,cerebral vascular resistance was significantly lower than that of control group at 150 min after treatment,whereas the effect of Goutengsan at 180 min was most obvious and continued to 210 min.Conclusion Goutengsan could significantly increase the blood flow of brain,reduce the cerebral vascular resistance,thus improved the brain nutritious condition and prevented the occurrence of senile dementia.

Key words: Goutengsan, Dog, Cerebral blood flow