关键词: 脑血流, 经颅多普勒, 麻醉剂, 水合氯醛

Abstract: Objective To study the effect of the commonly used anesthetic,chloral hydrate,on the cerebral blood flow in Wistar rats,and to discuss the relevant factors that affect cerebral blood flow in experimental animals.Methods Thirty Wistar rats were divided into three groups,the normal group,the sham group,and the model group.After anesthesia in three different time periods(10,30,and 50 minutes),the cerebral blood flow was tested.Results The cerebral blood flow of experimental groups after anesthesia in 10,30,and 50 minutes was increased conspicuously,and there was highly significant difference between the two experimental groups at the same time(P<0.01).Conclusion The cerebral blood flow was significantly affected by anesthesia in different periods.After anesthesia,it is essential to monitor the cerebral blood flow in experimental animals simultaneously.

Key words: Cerebral blood flow, Transcranial doppler, Anesthetic chloral hydrate