关键词: 天丰素, 糖尿病, 实验性/治疗, 大鼠

Abstract: Objective To observe the effect of brassinolide abstracted from pollen on the levels of blood glucose in diabetes rats.Methods One hundred and forty-four diabetes rats induced by Alloxan were randomly divided into Brassinolide group(treated with Brassinolide at 200,100,and 50 mg/kg respectively),control group(sodium chloride),and Phenformin group.After oral administration of Brassinolide for consecutive 7 days(once every day),the levels of blood glucose were evaluated on the day 0 and the day 7.This experiment was repeated twice.Results Before administration of Brassinolide,the levels of blood glucose were between 19.71 mmol/L and 24.10 mmol/L,then the levels decreased to the extent between 9.89 mmol/L and 12.70 mmol/L after administration of Brassinolide.The levels of blood glucose in the Phenformin group reduced from 20.92 mmol/L to 8.25 mmol/L after treatment.Both of Brassinolide and Phenformin had the similar effect to lower the blood glucose levels.Conclusion Brassinolide has the similar function of reducing the blood glucose levels as Phenformin,but not in a dose-dependent manner.The levels of blood glucose displayed significant differences after treatment with different dose of Brassinolide.The results indicated that Brassinolide,even at a lower dose,can still reduce the blood glucose levels without toxicity effect.It could provide a new idea for clinical treatment on diabetes.

Key words: Brassinolide, Diabetes, Experimental/therapy, Rats