葛花茯苓片的解酒作用及其机制

实验动物科学

葛花茯苓片的解酒作用及其机制

王会肖;刘继锋;白玉;吴文博;何立泽;

华北制药集团新药研究开发有限责任公司;石家庄市中医院;

收稿日期:2009-12-28 修回日期:2009-12-28 出版日期:2009-12-28 发布日期:2009-12-28

Anti-Inebriation Effects of Flos Puerariae-Poria Tablet and Its Mechanisms

WANG Hui-xiao~1,LIU Ji-feng~1,BAI-Yu~1,WU Wen-bo~2,HE Li-ze~1

(1.New Drug Research and Development Co.Ltd,North China Pharmaceutical Group Corporation Shijiazhuang 050015,China) (2.Shijiazhuang Municipal Hospital of Traditional Chinese Medicine,Shijiazhuang 050015,China

Received:2009-12-28 Revised:2009-12-28 Online:2009-12-28 Published:2009-12-28

摘要/Abstract

摘要： 目的探讨葛花茯苓片的解酒作用及相关机制。方法应用56°白酒,分别观察葛花茯苓片对急性酒精中毒小鼠的醉酒时间,睡眠时间,肝脏组织中的谷胱甘肽(GSH)、丙二醛(MDA)及乙醇脱氢酶(ADH)含量的影响。结果葛花茯苓片能延长醉酒时间,缩短睡眠时间,并能明显提高小鼠肝组织GSH、ADH水平和抑制酒精引起的MDA含量的增加。结论葛花茯苓片具有显著的解酒作用,这可能与其提高肝组织GSH、ADH水平和抑制MDA等的抗氧化作用有关。

关键词: 葛花茯苓片, 解酒作用, 还原型谷胱甘肽, 丙二醛, 乙醇脱氢酶

Abstract: Objective To investigate the anti-inebriation effect of Flos Puerariae-Poria Tablet and related its mechanisms.Methods The 56% vol.of liquor was orally administered into the mice to induce the alcoholism.Ebriety time and sober-up time were observed and recorded,and glutathione(GSH) malonaldehyde(MDA) levels and alcohol dehydrogenase(ADH) activity in liver were determined.Results Flos Puerariae-Poria Tablet prolonged the ebriety time and obviously shortened the sober-up time.In addition,Flos Puerariae-Poria Tablet could produce an increase in GSH content and enhance ADH activity,and could significantly block the increase of MDA induced by the liquor in hepatic tissue.Conclusion Flos Puerariae-Poria Tablet has effect of anti-inebriation,which is associated with its roles in enhancement of GSH content and ADH activity,and blocking the increase of MDA level.

Key words: Flos puerariae-poria tablet, Anti-inebriation effects, Glutathione, Malonaldehyde, Alcohol Dehydrogenase

王会肖;刘继锋;白玉;吴文博;何立泽;. 葛花茯苓片的解酒作用及其机制[J]. 实验动物科学.

WANG Hui-xiao~1,LIU Ji-feng~1,BAI-Yu~1,WU Wen-bo~2,HE Li-ze~1. Anti-Inebriation Effects of Flos Puerariae-Poria Tablet and Its Mechanisms[J]. laboratory animal science.

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