关键词: 健脾化湿颗粒, 肠易激综合征, 小肠运动, 离体实验

Abstract: Objective To observe the effect of Spleen-Invigorating and Dampness-Resolving Granule on the movement of small intestine of irritable bowel syndrome of deficiency of the spleen in rats.Methods Irritable bowel syndrome of spleen deficiency in the rats was developed by wrap restraint stress and administration of Sennae decoction for 2 weeks.The effect of spleen-invigorating and dampness-resolving granule on the activity of small intestine was analyzed by the advance rate of carbon powder in the small intestines and the frequency and amplitude of ex vivo intestinal canal.Results The movement of small intestine significantly quickened in model group(P<0.05)and significantly decreased after treatment(P<0.05).Conclusion Moderate dose and high dose of spleen-invigorating and dampness-resolving granule can improve diarrhea symptom,slower the movement of small intestine and have good curative effect on IBS.

Key words: Spleen-invigorating and dampness-resolving granule, Irritable bowel syndrome, Movement of small intestine, Experimental study