关键词: ApoE-/-小鼠, 动脉, 病理学

Abstract: Objective To investigate the pathological characteristic of main arteries in twelve-month-old ApoE-/-mice. Methods Both male and female ApoE-/-mice of twelve-month-old were selected in this study. Frozen sections were made from the aortic root, carotid artery, abdominal artery and renal artery, and stained with oil red O for examining the formation of atherosclerosis spots. Results Lipid plagues were detected in aortic roots and renal arteries of all ApoE-/-mice, and atherosclerotic plaques were observed in abdominal arteries of four ApoE-/-mice. No plaques were detected in carotid arteries of all mice. Conclusion ApoE-/-mice are the excellent animal model for atherosclerosis research.

Key words: Apolipoprotein E gene knock-out (ApoE-/-) mice, Artery, Pathological characteristic