关键词: 同种异体骨, 骨缺损, 骨移植, 动物模型

Abstract: Objective To explore the effect of new type of allograft bone in repairing bone defect. Method Male New Zealand rabbits were used to construct the animal model of bone injury, and 60 rabbits were randomly divided into experimental group, control group and blank control group. At the outer edge of proximal femur and 1 cm lower edge of greater trochanter, the bone defect with a depth of about 1 mm was prepared by precision grinding mechanism with a diameter of 4 mm ball head. Do the same for the contralateral femur. In the experimental group and control group, the left femoral defect was filled with cortical bone particles, and the right femoral defect was filled with cancellous bone fragments, and the material was filled with light pressure to make the material close to the hole as much as possible. Layered suture. Animals in the blank group underwent the same operation as described above without any material filling. Imaging ( X-ray) and histopathological examination were performed at 1, 4, 8 and 12 weeks after operation. Result One week after operation, there was no difference in bone defect repair among the three groups. At 4 weeks, 8 weeks and 12 weeks after operation, the bone tissue repair speed of the tested group was significantly better than that of the control group. Conclusion This type of allograft bone can stimulate the differentiation of mesenchymal cells into osteoblasts, promote the formation of osteocytes and the maturation of callus, and is an ideal bone graft material.

Key words: allogeneic bone, bone defect, bone graft, animal model