Abstract: Abstract: Objective To determine the difference of organs weight and blood physiological of CB6F1-Tg( HRAS) Nifdc Mice and CByB6F1-Tg( HRAS) 2Jic Mice. Method For this experiment, we selected 8-week-old CB6F1- NIFDC and CB6F1-CIEA mice ( 10 females and males ) of each sex, weighed body mass and subsequently dissected and assayed their major organ masses and blood physiology. Result There are some differents between the CB6F1-NIFDC and CB6F1-CIEA models in some parts of the organs and blood physiological parameters.Female mice showed some differences in heart, liver, lung and kidney, male mice showed differences in liver, lung, kidney, thymus and left and right testicular index mass. Among female mice, there were significant differences in 7 indicators ( RBC, HGB, etc. ) in 22 blood physiological parameters ( P < 0. 01) ; among male mice, there were significant differences in 5 indicators ( RBC, HCT, etc. ) in 22 blood physiological parameters ( P<0. 01) . Conclusion In this paper, the organ indicators and physiological indexes of the two models were measured, which may provide a reference for the application of the self-built model in the safety evaluation experiments of new drugs.

Key words: CB6F1-Tg ( HRAS ) Nifdc mice丨Japanese CByB6F1-Tg ( HRAS ) 2Jic mice丨organs weight, blood physiological丨carcinogenicity test丨drug safety evaluation