关键词: <, p>, 动物模型, 食源性过敏, 致敏潜力<, /p>

Abstract: Abstract: Food allergy is a common disease with high incidence． As the essential method for the study of food allergy，animal models are increasingly important． Although there has been some food allergy models for clinical diagnosis and research，they are not integrated． Herein，we review the design of animal models for food allergy． The dose threshold could obtain through the dose-sensititzation relationships to evaluate the allergic reaction． As the processing of protein changed，the sensitizability of the protein will changed as well． Here，the design of various animal models are reviewed， including among others considerations of species and strain， diet， route of administration，dose and formulation of the test protein，relevant controls and endpoints measured． Through the analysis and summary of the above aspects，this paper was expected to provide reference for the design of animal model for food allergy．

Key words: <p>animal models, food allergy, sensitizability</p>