关键词:
<, p>, 参竹精片, 抗疲劳作用, 抗氧化作用<, /p>

Abstract: Abstract: Objective To explore anti-fatigue and anti-oxidant effects of Shenzujing tablets in mice． Method One hundred and twenty mice were randomly divided into 5 groups: control groups，Liuwei Dihuang pill group and shenzujing tablets ( 0. 5，0. 25，0. 125 g / kg) groups． Each study group contained twenty-four mice． The mice received daily oral reatments of drugs for 7 days． The control group received daily oral treatments of isovolumic distilled water for 7 days． The 2 h after the last treatment，50% of mice tail root were randomly selected to load 2 grams of lead wire，the exhaustion swimming time were observed． The other 50% of the mice tail root were loaded 0. 4 grams of lead wire，after 1 hour swimming，SOD and MDA content in myocardium and muscle were detected． Another 144 mice were randomly divided into 6 groups: control group，model group，Liuwei Dihuang pill group and Shenzujing tablets ( 0. 5，0. 25，0. 125 g / kg) groups; The administration method were similar as above． After the last treatment，50% of mice were randomly selected and given intragastric administration of 0. 4 mL / 50% ethanol， serumand liver MDA，SOD content were determined，brain tissue of the other 50% mice were made into 10% brain homogenate and put Fe2 + － VitC solution in，hatched for 20 mins at temperature of 37 ℃，brain MDA，SOD content were determined． Ｒesult The mouse swimming exhaustion time in Shenzujing tablets ( 0. 25，0. 125 g / kg) groups were significantly prolonged( P ＜ 0. 05) ，and the myocardial SOD activity were significantly improved( P ＜ 0. 05) ． The MDA contents in biceps femoris muscle were lowered ( P ＜ 0. 05) ． serum and liver MDA concentration in alcoholic liver injury mice were lowered ( P ＜ 0. 01) ，SOD concentration were increased ( P ＜ 0. 01) ; MDA content in mice of the brain injury induced by Fe2 +－ VitC were reduced( P ＜ 0. 01) ． Conclusion The shenzujing tablets can increase SOD activity and decrease MDA accumulation and have the ability to maintain the body's metabolism，increase the mice swimming exhaustion time，good anti-fatigue effect，its effect is closely related to the anti oxidant effect．

Key words: <p>Shenzujing tablets, anti fatigue effect, anti oxidant effect</p>