关键词: <, p>, 阿尔茨海默病, 致病基因, AD 动物模型, 非人灵长类动物<, /p>

Abstract: Abstract: There are 8 － 10 million Alzheimer’s disease ( AD) patients in China at present． The number of patients is growing with population ageing year by year，however，there are still no effective ways to cure and reverse AD progression currently． The effective drugs screened for curing AD based on rodent animal models show poor effects or serious side effects on human trials，this mainly because the pathological and behavioral characteristics are significant different between the rodents animal models and AD patients． The brain and nervous system of nonhuman primate are highly similar to human，thus establish nonhuman primate model of AD is necessary and important． The AD etiology is complex，but the pathogenic gene mutations are clear documented． Hence it is time to pay attention on establishing nonhuman primate animal model of AD using the gene modification techniques or genetic screening analysis． This review mainly described the characteristics and status of AD pathogenic gene related genetically modified mice models and non-human primate animal models of AD．

Key words: <p>Alzheimer’s disease, pathogenic gene, animal model of AD, non-human primate</p>